The general instructions below apply to all journals published by the American Association for Cancer Research (AACR). Before you submit a manuscript for publication, please be sure to read and follow them. Also, please visit our Author Services Center where you will find various helpful tools and information relevant to publishing in AACR journals. Submission of a manuscript to an AACR journal implies that its author(s) understand and accept the policies of the journal and have complied with the Instructions for Authors, unless outlined otherwise in the cover letter accompanying the original submission.