([6R-(6α,6aα,8aβ,9α,11β,12aα,12bα,12cβ)]-decahydro-6-methyl-10-methylene-9H,13cH-8a,11-ethano-6,12b-propano-5H-benz[h]oxazolo[2,3-a]isoquinolin-9-01)-

Atisine

一枝蒿碱

Anthorine

343.49

熔点57～60°。盐酸盐(C22H33NO2·HCl)为扁平针状结晶(稀乙醇),熔点311～312°(分解),[α]25/D+28°。13CNMR(CDCl3)δ:42.0A,42.0B,(C-1),22.4A,21.7B(C-2),41.0A,40.9B(C-3),33.8A,28.2B(C-4),51.6A,48.9B(C-5),17.8A,18.5B(C-6),34.6A,32.0B(C-7),37.5A,37.5B(C-8),40.0A,39.6B(C-9),40.4A,40.4B(C-10),28.2A,28.2B(C-11),36.6A,36.6B(C-12),27.7A,27.7B(C-13),25.5A,25.5B(C-14),77.0A,77.0B(C-15),157.5A,157.5B(C-16),108.9A,108.4B(C-17),26.7A,26.1B(C-18),56.4A,53.3B(C-19),93.9A,94.2B(C-20),50.3A,50.3B(C-21),64.1A,59.2B(C-22)。A、B表示δ值为Atisine的两种善向异构体的δ值。

作退热剂应用。

毛莨科植物雪上一枝蒿(铁棒锤) Aconitum anthora L.根 异叶乌头 A.heterophyllum Wall.。

1.《植物药有效成分手册》人民卫生出版社1986

C22H33NO2