孙玉洁,博士,特聘教授,博士生导师
细胞生物学与医学遗传学系主任
研究方向:B细胞淋巴瘤形成的分子生物学机制
地址:南京市汉中路140号细胞生物学与医学遗传学系
邮编:210029
电话:025-86862731
E-mail:yujiesun@njmu.edu.cn
医学全在.线www.med126.com
孙玉洁,女, 特聘教授,博士生导师, 1984年获武汉同济医科大学医学遗传专业硕士学位,同年进入南京医科大学任教,1991年赴德国维尔茨堡大学攻读博士学位,1996年9月获人类遗传学博士学位。 1996年10月赴美国洛杉矶City of Hope National Medical Center分子医学系工作,重点研究染色体易位、原癌基因激活及B细胞巴瘤形成间的关系及其分子生物学机制。2003年元月回国工作,被南京医科大学聘为特聘教授和博士生导师, 细胞生物学和医学遗传学系主任及学科带头人。 目前主持承担国家自然科学基金、江苏省重点招标项和江苏省卫生厅科研项目各一项,已招收博士后两人、博士生6人,硕士研究生6人。主要研究方向:(1)BCL2原癌基因调控的分子生物学机制极其在肿瘤发生和发展中的作用;(2)寻找乳腺癌和大肠癌转移过程的生物标志物(3)用基因工程的方法结合动物模型筛选和研发抗肿瘤药物。
Main Publications (2001-2007)
1.Changyan Ma, Jingjing Zhang, Linda K Durrin. Jinghuan Lv, Dongya Zhu Xiao Han, and Sun Y.(2007). The BCL2 major breakpoint region (mbr) regulates gene expression. Oncogene 19; 26 (18): 2649-57 [Epub 2006 Oct 23].
2. Zhang JJ, Ma CY, Han X,Durrin L, and Sun Y.(2006). The BCL2 major breakpoint region (mbr) possesses transcriptional regulatory function. Gene 379:127-131.
3. Men Z, Sun J, Ling J, Lv J, Zhu DY, Chen Q, Sun Y* and Han X*. (2006) Prostaglandin E2 regulates Foxo activity via the Akt pathway: implications for pancreatic islat beta-cell dysfunction. Diabetologia Oct 11 [Epub ahead of print]. *Co-corresponding authors.
4. Sun Y, Wang T, Yin Y, Xu S, Ma C, Han X. (2006). The behavior of SATB1, a MAR binding protein, in response to apoptosis stimulation. Cell Biology International. 30(3):244-247.
5. Wang Z, Lv JH, Zhang RH, ZyX, Sun Y*, Zhu J, Han X*. (2006). Co-culture with fat cells induces insulin resistance in primary hepatocytes. BBRC 345 (3):976-83. *Co-corresponding authors.
6. Lin J, Sun Y, Zhu D, Chen Q and Han X. Potential role of NO in modulation of COX-2 expression and PGE2 production in pancreatic β-cells. (2005). Acta Biochimica et Biophysica Sinica 37(2):139-146.
7. Sun Y, Durrin, LK, Krontiris TG. (2003). Specific interaction of PML bodies with the TP53 locus in Jurkat Interphase Nuclei. Genomics 82(2):250-258.
8. Sun Y, Wyatt RT, Bigley A, Krontiris TG. (2001). Expression and replication timing patterns of wild type and translocated BCL2 genes. Genomics 73(2): 161-170.
9. Sun Y. and Han X. (2001). Detection of the specific translocation of BCL2 gene with immunofluorescence in situ hybridization (FISH) method in interphase nuclei. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 6: 472-475.
10. Han X, Sun Y, Stephen Scott, and David Bleich. (2001). Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) prevents cytokine-mediated dysfunction and cytotoxicity in pancreatic islets and b-cells. Diabetes. 50(5): 1047-55.
11. Han X, Chen S, Sun Y, Jerry L. Nadler, and Bleich D. (2002). Induction of cyclooxygenase-2 (COX-2) gene in pancreatic beta cells by 12-lipoxygenase pathway product 12-hydroxyeicosatetraenoic acid (12-HETE). Molecular Endocrinology. 19: 2145-2154.