近年负责的研究课题:
1. 核糖核苷酸还原酶小亚基结构位点特异性抗肿瘤先导化合物设计与活性研究。国家自然科学基金项目,2009.1-2011.12。
2. 低浓度致癌物MNNG诱导TLS聚合酶基因表达改变的转录调控。国家自然科学基金项目,2008.1-2010.12。
3. 邵吉民研究团队。浙江省自然科学基金杰出人才团队项目www.med126.com,2008.1-2010.12。
4. 核糖核苷酸还原酶亚基特异性抗肿瘤药物设计与生物活性研究。浙江省科技计划项目,2008.1-2010.12。
5. STAT5b 信号通路分子乙酰化激活及其在乳腺癌生长和转移中作用的分子机制. 国家教育部高等学校博士学科点专项科研基金,2010.1-2012.12.
6. 环境化学污染物应答基因的筛选鉴定和重要应答基因的表达调控研究。973国家重点基础研究发展规划项目课题(项目学术骨干),2002.12- 2008.12。
7. 人核糖核苷酸还原酶小亚基活性机制及其与小分子化学抑制物相互作用研究。国家教育部留学回国人员科研启动基金,2008.1-2009.12。
8. 人核糖核苷酸还原酶小亚基活性特点及其小分子化学抑制物选择性作用机制。国家人事部留学回国人员科研启动基金,2007.1-2008.12。
9. 人核糖核苷酸还原酶小亚基活性机制及其与小分子化学抑制物相互作用的研究。浙江省留学回国人员科研启动费,2006.1-2007.12.
10. 浙江大学引进人才科研启动基金,2005.10。
近年代表性论文
(1) Zhu H, Fan Y, Jiang H, Shen J, Qi H, Mei R, Shao J*. Response of human DNA polymerase promoter to N-methyl-N\'-nitro-N-nitrosoguanidine. Environmental Toxicology and Pharmacology 2010;29 (1) :79–86. (*Corresponding author)
(2) Lu X#, Shao J#, Li H, Yu Y. Temporal gene expression changes induced by a low concentration of benzo[a]pyrene diol epoxide in a normal human cell line. Mutation Research 2010;684(1-2):74-80. (# Co-first authors).
(3) Zhu L, Zhou B, Chen X, Jiang H, Shao J*, Yen Y*. Inhibitory mechanisms of heterocyclic carboxaldehyde thiosemicabazones for two forms of human ribonucleotide reductase. Biochemical Pharmacology 2009;78:1178-1185. (*Co-corresponding authors)
(4) Lu X#, Shao J#, Li H, Yu Y. Early whole-genome transcriptional response induced by benzo(a)pyrene diol epoxide in a normal human cell line. Genomics 2009; 93:332-342.
(5) Li H#, Shao J#, Lu X, Gao Z, Yu Y. Identification of early responsive genes in human amnion epithelial FL cells induced by N-methyl-N\'-nitro-N-nitrosoguanidine using oligonucleotide microarray and quantitative real-time RT-PCR approaches. Mutation Research 2008;644(1-2):1-10.www.med126.com
(6) Shao J, Zhou B, Zhu L, Di Bilio A, Yen Y. A Ferrous-triapine Complex Mediates Formation of Reactive Oxygen Species That Inactivate Human Ribonucleotide Reductase. Molecular Cancer Therapeutics 2006;5(3): 586-592.
(7) Shao J, Zhou B, Chu B, Yen Y. Ribonucleotide Reductase Inhitiors and future drug design. Current Cancer Drug Targets 2006;6(5):409-431.
(8) Qiu W, Zhou B, Darwish D, Shao J, Yen Y. Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits. Biochemical and Biophysical Research Communications 2006;340(2):428-434.
(9) Zhu L, Yen Y, Shao J, Qi C, Yen C, Luo J, Zhou B. Fibroblast Growth Factor Receptor 3 Up-Regulates Vascular Endothelial Growth Factor Expression In L6 Cells. International Journal of Pharmacology 2006;2(3):324-330.
(10) Shao J, Zhou B, Zhu L, Di Bilio AJ, Su L, Yuan Y, Ren S, Lien EJ, Shih J, Yen Y. Determination of the potency and subunit-selectivity of ribonucleotide reductase inhibitors with a recombinant-holoenzyme-based in vitro assay. Biochemical Pharmacology 2005; 69: 627–634.