5

Wang B, Yang L, Wang Z and Zheng H* (2007) Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter. Proc. Natl. Acad. Sci. USA .104: 14140-14145. （影响因子10.789)

6

Wang R, Tang P, Wang P, Boissy RE and Zheng H* (2006) Regulation of tyrosinase trafficking and processing by presenilins: Partial loss of function by familial Alzheimer’s disease mutation. Proc. Natl. Acad. Sci. USA .103: 353-358.（影响因子10.789)

7

Deng Y, Tarassishin L, Kallhoff V, Peethumnongsin E, Wu L, Li Y, Zheng H* (2006) Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. J. Neurosci. 26(14): 3845-54. （影响因子7.452)

8

Xia X, Wang P, Sun X, Soriano S, Shum W-K, Trumbauer ME, Takashima A, Koo EH, and Zheng H* (2002) The aspartate-257 of presenilin 1 is indispensable for mouse development and production of b-amyloid peptides through b-catenin independent mechanisms. Proc. Natl. Acad. Sci. USA. 99(13):8760-5（影响因子10.789)

9

Xia X, Qian S, Soriano S, Wu Y, Fletcher A, Wang X-J, Koo EH, Wu X, and Zheng H* (2001) Loss of presenilin 1 is associated with enhanced -catenin signaling and skin tumorigenesis. Proc. Natl. Acad. Sci. USA. 98: 10863-10868. www.med126.com（影响因子10.789)

10

Qian S, Jiang P, Guan X, Singh G, Trumbauer ME, Hong Y, Chen HY, Van der Ploeg LHT and Zheng H* (1998) Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta 42/43 expression. Neuron. 20: 611-617. (影响因子14.17)

获奖：

1

2000-2004, New Scholars Award, Ellison Medical Foundation

2

2004-2006, Zenith Award, Alzheimer’s Association