主要学术成果：

论文：

1

Liu Q, Zhang J, Zerbinatti C, Zhan Y, Kolber BJ, Herz J, Muglia LJ, Bu G* (2011) Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. PLoS Biol. 9(1):e1000575. （影响因子12.683)

2

Liu CC, Prior J, Piwnica-Worms D, Bu G*(2010) LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy. Proc. Natl. Acad. Sci. USA.107:5136-5141. （影响因子10.789)

3

Bu G* (2009) Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nat Rev Neurosci.10:333-344. （影响因子25.94)

4

Zhang J, Li Y, Liu Q, Lu W, Bu G* (2010)Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis. Oncogene. 29(4):539-49. （影响因子7.216)

5

van Kerkhof P, Lee J, McCormick L, Tetrault E, Lu W, Schoenfish M, Oorschot V, Strous GJ, Klumperman J, Bu G* (2005)Sorting nexin 17 facilitates LRP recycling in the early endosome. EMBO J. 17;24(16):2851-61. （影响因子10.65)

6

Kanekiyo T, Zhang J, Liu Q, Liu CC, Zhang L, Bu G*(2011) Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-bata uptake J Neurosci.31(5):1644-51.（影响因子7.452)

7

Liu Q, Trotter J, Zhang J, Peters MM, Cheng H, Bao J, Han X, Weeber EJ, Bu G*(2010)Impaired brain lipid metabolism in lipoprotein receptor-deficient mice leads to progressive, age-dependent synapse loss and neurodegeneration. J Neurosci. 30(50):17068-78. （影响因子7.452)

8

Song H, Li Y, Lee J, Schwartz AL, Bu G* (2009)Low-density lipoprotein receptor-related protein 1 promotes www.med126.com cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9. Cancer Res. 69(3):879-86.( 影响因子7.514)

9

Liu Q, Zerbinatti CV, Zhang J, Hoe HS, Wang B, Cole SL, Herz J, Muglia L, Bu G * (2007) Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron.56:66-78. （影响因子14.17)

10

Zerbinatti CV, Wozniak DF, Cirrito J, Cam JA, Osaka H, Bales KR, Zhuo M, Paul SM, Holtzman DM, Bu G * (2004) Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. Proc. Natl. Acad. Sci. USA.101(4):1075-1080. （影响因子10.789)