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 医学全在线 > 考研院校 > 华东地区1 > 中科院上海药物研究所 > 导师信息 > 正文
中科院上海药物研究所院士丁健导师信息
来源:本站原创 更新:2012/7/3 字体:

社会任职: 
 
获奖及荣誉:
国家自然科学奖二等奖(2009)
国家科技进步二等奖(2003)
上海市自然科学一等奖(2项,2007,2010)
上海市科技进步一等奖(2003)
何梁何利科技进步奖(2008)
吴阶平医学研究奖-保罗•杨森药学研究一等奖(2006)
上海市十大科技精英(2005)
第四届德彪-CCRF一等奖(2001)
中科院优秀研究生导师(2004,2005)
 

代表论著
Ai J, Tang QJ, Wu YL, Xu Y, Feng T, Zhou RY, Chen Y, Gao X, Zhu QF, Yue XH, Pan QN, Xu SY, Li J, Huang M, Daugherty-Holtrop J, He YZ, Xu HE, Fan J*, Ding J*, Geng MY*. The Role of Polymeric Immunoglobulin Receptor in Inflammation-Induced Tumor Metastasis of Human Hepatocellular Carcinoma.  J Natl Cancer Inst. 103:1696-712, 2011
Jiang Y., Miao ZH*., Xu L., Yu B., Gong JX., Tong LJ., Chen Y., Zhou ZL., Liu HC., Wang Y., Guo YW., Ding J*.  Drug transporter-independentliver cancer cell killing by marine steroid methyl spongoate via intrinsic and extrinsic apoptosis pathways.  J Biol Chem 286:26461-9, 2011
Xie H., Lin LP., Tong LJ., Jiang Y., Zheng MY., Jiang XY., Zhang XW., Ren XW., Qu WC., Yang Y., Wan H., Chen Y., Zuo JP., Jiang HL., Geng MY., Ding J*.  AST1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo.  Plos One  6:e21487, 2011
Zhang J, Xin X, Chen Q, Xie Z, Gui M, Chen Y, Lin L, Feng J, Li Q, Ding J*, Geng M*. Oligomannurarate sulfate www.med126.com  sensitizes cancer cells to doxorubicin by inhibiting atypical activation of NF-κB via targeting of Mre11.  Int J Cancer. 130: 467–477, 2012
Zhu CH., Chen Q., Xie ZQ., Ai J., Tong LJ., Ding J*., Geng MY*.  The role of histone deacetylase 7 (HDAC 7) in cancer cell proliferation: regulation on c-Myc.  J Mol Med  89: 279-89, 2011
Zhang ZX., Meng T., Yang N., Wang W., Xiong B., Chen Y., Ma LP., Shen JK., Miao ZH*, Ding J*.  MT119, a new planar-structured compound, targets the colchicine site of tubulin arresting mitosis and inhibiting tumor cell proliferation.  Inter J Cancer  129: 214-24, 2011.
Chen G, Yang N, Wang X, Zheng SY, Chen Y, Tong LJ, LI YX, Meng L*., Ding J*.. Identification of p27/KIP1 expression level as a candidate biomarker of response to rapalogs therapy in human cancer.  J Mol Med  88: 941-52, 2010
Li M, Miao ZH, Chen Z, Chen Q, Gui M, Lin LP, Sun P, Yi YH, Ding J*.  Echinoside A, a new marine-derived www.med126.com  anticancer saponin, targets topoisomerase II by unique interference with its DNA binding and catalytic cycle.  Ann Oncol  21: 597-607, 2010.
Li T, Wang J, Wang X, Yang N, Chen SM, Tong LJ, Yang CH, Meng LH, Ding J*. WJD008, a dual phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin inhibitor, prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutant. J Pharmacol Exp Ther. 334:830-8, 2010
Lu JJ., Meng LH*., Shankavaramb UT., Zhu CH., Tong LJ., Chen G., Lin LP.,  Weinsteinc JN., Ding J*.  Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells.  Biochem Pharmacol  80: 22-30, 2010.
Yu B, Miao ZH, Jiang Y, Li MH, Yang N, Li T, Ding J*. c-Jun Protects Hypoxia-Inducible Factor-1{alpha} from Degradation via Its Oxygen-Dependent Degradation Domain in a Nontranscriptional Manner.  Cancer Res.  69:7704-12, 2009

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