1.具有重要生理活性的天然产物合成和构效关系研究；2.针对抗肿瘤药物的新靶点如端粒酶（telomerase)、组蛋白脱乙酰酶（HDAC)和表皮生长因子受体（ EGFR)等医学全在,线www.med126.com，设计和合成具有新型作用机制的抗肿瘤药物；3.有机小分子催化的不对称反应研究

1. Guangshun Luo, Wenhu Duan,* Wei Wang. Enatioselective organocatalytic synthesis of highly functionalized tetrahydrothiophenes by a Michael-aldol cascade reaction. Tetrahedron Letters 2009, 50, 2946–2948.
2. Guangshun Luo, Wenhu Duan,* Wei Wang*. Enantioselective Conjugate Addition of N-Heterocycles to α,β-Unsaturated Ketones Catalyzed by Chiral Primary Amines. Synthesis 2009, 564-1572.
3. Lirong Song, Wenhu Duan* and Wei Wang.* An Organocatalytic Approach to the Construction of Chiral Oxazolidinone Rings and Application in the Synthesis of Antibiotic Linezolid and Its Analogues. Organic Letters 2008, 10 (23), 5489–5492.
4. Fei Xue, Wenhu Duan,* Wei Wang.* A Novel Bifunctional Sulfonamide Primary Amine-Catalyzed Enantioselective Conjugate Addition of Ketones to Nitroolefins. Advanced Synthesis & Catalysis 2008, 350, 2194-2198.
5. Kui Mei, Wenhu Duan,* Wei Wang. Asymmetric direct aldol reactions of aryl methyl ketones with aryl aldehydes. Tetrahedron Letters 2008, 49(17), 2681-2684