制药工程与技术；合成药物化学:

1 绿色高效合成方法研究

2 重点药物品种的合成工艺研究

3 基于临床及绿色高效合成方法的新药（包括抗肿瘤药物www.med126.com、抗抑郁症药物、抗艾滋病药物和抗菌药物等)设计与合成

1) Organocatalysis: asymmetric cascade reactions catalysed by chiral secondary amines. Org. Biomol. Chem., 2008, 6, 2037
2) Hydrogen-bond-mediated asymmetric catalysis. Chem. Asian J., 2008, 3，516
3)Chiral amine catalysed enantioselective cascade aza-ene-type cyclization reactions. Chem. Eur. J., 2008, 14,6333
4) Microwave-assisted www.med126.com three-component Knoevenagel-nucleophilic aromatic substitution reactions. Tetrahedron Lett., 2008, 49，4687
5) Chiral Pyrrolidine Sulfonamide Catalyzed Enantioselective Michael Addition of Cyclohexanones to Maleimides. Synlett, 2011, (4): 473-476.
6)Total synthesis of polyene natural product dihydroxerulin by mild organocatalyzed dehydrogenation of alcohols. Chem. Eur. J, 2012, 18(8),2230-2234.
7) A new facile approach to N-alkylpyrroles from direct redox reaction of 4-hydroxy-L-proline with aldehydes. Sci. China–Chem, 2012, 55(1), 43-49.